Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM50133716 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_89932 |
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IC50 | 210±n/a nM |
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Citation | Dhar, TG; Shen, Z; Gu, HH; Chen, P; Norris, D; Watterson, SH; Ballentine, SK; Fleener, CA; Rouleau, KA; Barrish, JC; Townsend, R; Hollenbaugh, DL; Iwanowicz, EJ 3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett13:3557-60 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM50133716 |
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n/a |
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Name | BDBM50133716 |
Synonyms: | CHEMBL118115 | {3-[2-(3-Cyano-1-methyl-1H-indol-6-ylamino)-oxazol-5-yl]-benzyl}-carbamic acid 2-dimethylamino-ethyl ester |
Type | Small organic molecule |
Emp. Form. | C25H26N6O3 |
Mol. Mass. | 458.5123 |
SMILES | CN(C)CCOC(=O)NCc1cccc(c1)-c1cnc(Nc2ccc3c(cn(C)c3c2)C#N)o1 |
Structure |
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