Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50569038 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2107361 (CHEMBL4816036) |
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Ki | 17±n/a nM |
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Citation | Shaldam, M; Eldehna, WM; Nocentini, A; Elsayed, ZM; Ibrahim, TM; Salem, R; El-Domany, RA; Capasso, C; Abdel-Aziz, HA; Supuran, CT Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors. Eur J Med Chem216:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50569038 |
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n/a |
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Name | BDBM50569038 |
Synonyms: | CHEMBL4855981 |
Type | Small organic molecule |
Emp. Form. | C15H12BrClN4O6S2 |
Mol. Mass. | 523.766 |
SMILES | NS(=O)(=O)c1cc(c(NC(=O)Nc2cc3cc(Br)ccc3o2)cc1Cl)S(N)(=O)=O |
Structure |
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