| Reaction Details |
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 | Report a problem with these data |
| Target | Neutral ceramidase |
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| Ligand | BDBM50569051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2107504 (CHEMBL4816179) |
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| Ki | 2000±n/a nM |
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| Citation |  Bielsa, N; Casasampere, M; Aseeri, M; Casas, J; Delgado, A; Abad, JL; Fabriās, G Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells. Eur J Med Chem216:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutral ceramidase |
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| Name: | Neutral ceramidase |
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| Synonyms: | ASAH2 | ASAH2_HUMAN | Acylsphingosine deacylase 2 | BCDase | HNAC1 | LCDase | N-CDase | N-acylsphingosine amidohydrolase 2 | NCDase | Neutral ceramidase soluble form | Non-lysosomal ceramidase | hCD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85523.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_947546 |
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| Residue: | 780 |
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| Sequence: | MAKRTFSNLETFLIFLLVMMSAITVALLSLLFITSGTIENHKDLGGHFFSTTQSPPATQG
STAAQRSTATQHSTATQSSTATQTSPVPLTPESPLFQNFSGYHIGVGRADCTGQVADINL
MGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQRLRLEVLNRLQSKYG
SLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSIDIAHTNMKP
GKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGLISWF
AIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGP
RCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRAKELYASASQEVT
GPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDPFW
DTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGE
FTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGP
HTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQ
PAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFY
WHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPAVILSFEGTSPAFEVVTI
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| BDBM50569051 |
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| n/a |
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| Name | BDBM50569051 |
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| Synonyms: | CHEMBL4865548 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H49NO2 |
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| Mol. Mass. | 395.6621 |
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| SMILES | CCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](C)NC(=O)CCCCCCC |r| |
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| Structure | 
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