Ki Summary

Reaction Details

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Target

Prolyl endopeptidase

Ligand

BDBM50134158

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_223468 (CHEMBL874055)

IC50

87±n/a nM

Citation

Wallén, EA; Christiaans, JA; Jarho, EM; Forsberg, MM; Venäläinen, JI; Männistö, PT; Gynther, J New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides. J Med Chem46:4543-51 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prolyl endopeptidase

Name:

Prolyl endopeptidase

Synonyms:

3.4.21.26 | PE | PPCE_PIG | PREP | Post-proline cleaving enzyme

Type:

n/a

Mol. Mass.:

80758.04

Organism:

Sus scrofa

Description:

n/a

Residue:

710

Sequence:

MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT
LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP

BDBM50134158

n/a

Name

BDBM50134158

Synonyms:

CHEMBL142133 | N-((R)-1-Methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-N'-((S)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-isophthalamide

Type

Small organic molecule

Emp. Form.

C22H30N4O4

Mol. Mass.

414.498

SMILES

C[C@@H](NC(=O)c1cccc(c1)C(=O)N[C@@H](C)C(=O)N1CCCC1)C(=O)N1CCCC1

Structure