| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
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| Ligand | BDBM50569302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2108812 (CHEMBL4817487) |
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| Ki | 4.0±n/a nM |
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| Citation |  Rancati, F; Linney, ID; Rizzi, A; Delcanale, M; Knight, CK; Schmidt, W; Pastore, F; Riccardi, B; Mileo, V; Carnini, C; Cesari, N; Blackaby, WP; Patacchini, R; Carzaniga, L Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and ? Bioorg Med Chem Lett41:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M3 |
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| Name: | Muscarinic acetylcholine receptor M3 |
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| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 66151.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20309 |
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| Residue: | 590 |
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| Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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| BDBM50569302 |
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| n/a |
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| Name | BDBM50569302 |
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| Synonyms: | CHEMBL4878138 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H42ClN5O7 |
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| Mol. Mass. | 740.244 |
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| SMILES | COc1cc(C(=O)NCCN2CCC(CC2)OC(=O)Nc2ccccc2-c2ccccc2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 |r| |
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| Structure | 
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