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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-2 adrenergic receptor | ||
| Ligand | BDBM50569294 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2108813 (CHEMBL4817488) | ||
| Ki | 0.015849±n/a nM | ||
| Citation |  Rancati, F; Linney, ID; Rizzi, A; Delcanale, M; Knight, CK; Schmidt, W; Pastore, F; Riccardi, B; Mileo, V; Carnini, C; Cesari, N; Blackaby, WP; Patacchini, R; Carzaniga, L Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and ? Bioorg Med Chem Lett41:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Beta-2 adrenergic receptor | |||
| Name: | Beta-2 adrenergic receptor | ||
| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor | ||
| Type: | n/a | ||
| Mol. Mass.: | 46461.69 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07550 | ||
| Residue: | 413 | ||
| Sequence: |
| ||
| BDBM50569294 | |||
| n/a | |||
| Name | BDBM50569294 | ||
| Synonyms: | CHEMBL4863525 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C38H46N4O6 | ||
| Mol. Mass. | 654.795 | ||
| SMILES | O[C@@H](CNCCCCCCOc1cccc(c1)C(NC(=O)O[C@H]1CN2CCC1CC2)c1ccccc1)c1ccc(O)c2[nH]c(=O)ccc12 |r,wU:22.22,1.0,(-.19,-37.45,;1.15,-38.22,;2.48,-37.45,;3.82,-38.21,;5.15,-37.44,;6.49,-38.2,;7.82,-37.43,;9.15,-38.2,;10.48,-37.42,;11.82,-38.19,;13.15,-37.41,;14.49,-38.19,;14.48,-39.72,;15.82,-40.49,;17.15,-39.72,;17.14,-38.17,;15.8,-37.41,;18.47,-37.38,;19.81,-38.15,;21.14,-37.37,;21.13,-35.83,;22.48,-38.13,;23.81,-37.35,;23.79,-35.82,;25.13,-35.05,;26.47,-35.82,;26.47,-37.36,;25.14,-38.13,;25.84,-36.77,;24.35,-36.38,;18.46,-35.85,;19.79,-35.08,;19.79,-33.54,;18.45,-32.77,;17.12,-33.56,;17.13,-35.09,;1.16,-39.76,;-.18,-40.53,;-.18,-42.07,;1.16,-42.85,;1.16,-44.39,;2.49,-42.07,;3.82,-42.84,;5.16,-42.07,;6.49,-42.85,;5.16,-40.53,;3.82,-39.75,;2.49,-40.52,)| | ||
| Structure | 
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