| Reaction Details |
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 | Report a problem with these data |
| Target | Carbapenem-hydrolyzing beta-lactamase KPC |
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| Ligand | BDBM50569705 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2109934 (CHEMBL4818609) |
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| Ki | 4150±n/a nM |
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| Citation |  Romero, E; Oueslati, S; Benchekroun, M; D'Hollander, ACA; Ventre, S; Vijayakumar, K; Minard, C; Exilie, C; Tlili, L; Retailleau, P; Zavala, A; Elisée, E; Selwa, E; Nguyen, LA; Pruvost, A; Naas, T; Iorga, BI; Dodd, RH; Cariou, K Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of ?-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D). Eur J Med Chem219:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbapenem-hydrolyzing beta-lactamase KPC |
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| Name: | Carbapenem-hydrolyzing beta-lactamase KPC |
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| Synonyms: | BLKPC_KLEOX | Carbapenem-hydrolyzing beta-lactamase KPC-2 | bla | kpc | kpc2 |
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| Type: | Protein |
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| Mol. Mass.: | 31116.99 |
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| Organism: | n/a |
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| Description: | Q848S6 |
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| Residue: | 293 |
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| Sequence: | MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYR
AEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAE
LSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTS
SPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVY
GTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
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| BDBM50569705 |
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| n/a |
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| Name | BDBM50569705 |
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| Synonyms: | CHEMBL4853896 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15Cl2IN2O2 |
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| Mol. Mass. | 537.177 |
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| SMILES | OC(=O)c1ccc(cc1)N1C(C\C1=N/c1ccc(I)cc1)c1ccc(Cl)cc1Cl |
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| Structure | 
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