| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50135499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_49439 |
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| IC50 | 159±n/a nM |
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| Citation |  Masaki, H; Mizuno, Y; Tatui, A; Murakami, A; Koide, Y; Satoh, S; Takahashi, A Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors. Bioorg Med Chem Lett13:4085-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
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| Type: | Enzyme |
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| Mol. Mass.: | 27340.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 247 |
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| Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
|
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|
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| BDBM50135499 |
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| n/a |
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| Name | BDBM50135499 |
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| Synonyms: | 2-[4-(5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonylamino)-3-methanesulfonyl-benzoylamino]-3-hydroxy-propionic acid | CHEMBL131605 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19FN2O8S3 |
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| Mol. Mass. | 530.567 |
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| SMILES | Cc1c(sc2ccc(F)cc12)S(=O)(=O)Nc1ccc(cc1S(C)(=O)=O)C(=O)NC(CO)C(O)=O |
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| Structure | 
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