| Reaction Details |
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 | Report a problem with these data |
| Target | Furin |
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| Ligand | BDBM50571192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2114072 (CHEMBL4822922) |
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| IC50 | 290±n/a nM |
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| Citation |  Elseginy, SA; Fayed, B; Hamdy, R; Mahrous, N; Mostafa, A; Almehdi, AM; S M Soliman, S Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases. Bioorg Med Chem Lett43:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Furin |
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| Name: | Furin |
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| Synonyms: | FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86676.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09958 |
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| Residue: | 794 |
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| Sequence: | MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
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| BDBM50571192 |
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| n/a |
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| Name | BDBM50571192 |
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| Synonyms: | CHEMBL4869416 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N5O9S |
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| Mol. Mass. | 555.517 |
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| SMILES | COc1cc(ccc1O)C(NC1=NC(=O)C(CC(=O)Nc2ccc(cc2)C(O)=O)S1)c1c(O)[nH]c(=O)[nH]c1=O |t:12| |
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| Structure | 
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