| Reaction Details |
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 | Report a problem with these data |
| Target | Integrin beta-7 |
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| Ligand | BDBM50070619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_217472 (CHEMBL819915) |
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| IC50 | 280000±n/a nM |
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| Citation |  Locardi, E; Boer, J; Modlinger, A; Schuster, A; Holzmann, B; Kessler, H Synthesis and structure-activity relationship of mannose-based peptidomimetics selectively blocking integrin alpha4beta7 binding to mucosal addressin cell adhesion molecule-1. J Med Chem46:5752-62 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrin beta-7 |
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| Name: | Integrin beta-7 |
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| Synonyms: | ITB7_HUMAN | ITGB7 | Integrin alpha-4/beta-7 | Integrin beta-7 precursor | Integrin beta7 |
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| Type: | Membrane Protein |
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| Mol. Mass.: | 86893.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P26010 |
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| Residue: | 798 |
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| Sequence: | MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPS
CAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGA
TQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLV
RLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQ
AFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKL
GGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELS
KLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREG
KAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSD
TQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGK
GHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSG
DMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTG
PLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKG
ADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKS
AITTTINPRFQEADSPTL
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| BDBM50070619 |
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| n/a |
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| Name | BDBM50070619 |
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| Synonyms: | (S)-N-((1S,2R)-1-Carbamoyl-2-hydroxy-propyl)-3-{(S)-2-[(isoquinoline-3-carbonyl)-amino]-4-methyl-pentanoylamino}-succinamic acid | CHEMBL409117 | N-(1-Carbamoyl-2-hydroxy-propyl)-3-{2-[(isoquinoline-3-carbonyl)-amino]-4-methyl-pentanoylamino}-succinamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N5O7 |
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| Mol. Mass. | 501.5322 |
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| SMILES | CC(C)C[C@H](NC(=O)c1cc2ccccc2cn1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
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| Structure | 
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