| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 4 |
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| Ligand | BDBM50572054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2116084 (CHEMBL4825025) |
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| Kd | 488±n/a nM |
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| Citation |  Baggio, C; Kulinich, A; Dennys, CN; Rodrigo, R; Meyer, K; Ethell, I; Pellecchia, M NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands. J Med Chem64:11229-11246 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 4 |
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| Name: | Ephrin type-A receptor 4 |
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| Synonyms: | EPHA4 | EPHA4_HUMAN | Ephrin receptor | Ephrin type-A receptor 4 | HEK8 | SEK | TYRO1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109859.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586961 |
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| Residue: | 986 |
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| Sequence: | MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIM
DEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKE
TFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK
DVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSV
WEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDI
SYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVS
KYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYE
KDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRII
GDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPF
TYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT
DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTV
IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT
TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG
YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNT
ALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAIT
HQNKILSSVQAMRTQMQQMHGRMVPV
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| BDBM50572054 |
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| n/a |
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| Name | BDBM50572054 |
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| Synonyms: | CHEMBL4859816 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H53N11O7 |
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| Mol. Mass. | 847.9611 |
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| SMILES | NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)NCC(=O)Nc1ncccc1O |r| |
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| Structure | 
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