| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Ligand | BDBM68853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2116448 (CHEMBL4825389) |
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| IC50 | 340±n/a nM |
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| Citation |  Tsai, WC; Gilbert, NC; Ohler, A; Armstrong, M; Perry, S; Kalyanaraman, C; Yasgar, A; Rai, G; Simeonov, A; Jadhav, A; Standley, M; Lee, HW; Crews, P; Iavarone, AT; Jacobson, MP; Neau, DB; Offenbacher, AR; Newcomer, M; Holman, TR Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2. Bioorg Med Chem46:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Synonyms: | 15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-Lipoxygenase-2 (15-LOX-2) | 15-lipoxygenase 2 | ALOX15B | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2 | LX15B_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 75850.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 676 |
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| Sequence: | MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE
GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK
NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS
QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV
RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL
IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI
WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ
YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVL
PYTYLDPPLIENSVSI
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| BDBM68853 |
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| n/a |
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| Name | BDBM68853 |
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| Synonyms: | 1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidazole | 1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylsulfanyl]imidazole | 1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole | 1-phenyl-2-{[4-(trifluoromethyl)benzyl]sulfanyl}-1H-imidazole | MLS000327069 | SMR000179722 | cid_3696046 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13F3N2S |
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| Mol. Mass. | 334.359 |
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| SMILES | FC(F)(F)c1ccc(CSc2nccn2-c2ccccc2)cc1 |
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| Structure | 
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