| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
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| Ligand | BDBM50572297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2116664 (CHEMBL4825605) |
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| Ki | 66±n/a nM |
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| Citation |  Fernández, A; Díaz, JL; García, M; Rodríguez-Escrich, S; Lorente, A; Enrech, R; Dordal, A; Portillo-Salido, E; Porras, M; Fernández, B; Reinoso, RF; Vela, JM; Almansa, C Piperazinyl Bicyclic Derivatives as Selective Ligands of the ?2?-1 Subunit of Voltage-Gated Calcium Channels. ACS Med Chem Lett12:1802-1809 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel subunit alpha-2/delta-1 |
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| Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
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| Synonyms: | CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2-1 | Voltage-dependent calcium channel subunit delta-1 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 1 | Voltage-gated calcium channel subunit alpha-2/delta-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 124544.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54289 |
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| Residue: | 1103 |
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| Sequence: | MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLL
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| BDBM50572297 |
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| n/a |
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| Name | BDBM50572297 |
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| Synonyms: | CHEMBL4856257 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H29BrN4O |
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| Mol. Mass. | 421.374 |
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| SMILES | CCCC(N1C[C@H](C)N[C@H](C)C1)c1nc2cccc(Br)c2c(=O)n1CC |r| |
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| Structure | 
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