| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50138020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_69826 (CHEMBL679575) |
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| IC50 | 1400±n/a nM |
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| Citation |  Ghosh, S; Chan, JM; Lea, CR; Meints, GA; Lewis, JC; Tovian, ZS; Flessner, RM; Loftus, TC; Bruchhaus, I; Kendrick, H; Croft, SL; Kemp, RG; Kobayashi, S; Nozaki, T; Oldfield, E Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem47:175-87 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48114.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1352847 |
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| Residue: | 417 |
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| Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
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| BDBM50138020 |
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| n/a |
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| Name | BDBM50138020 |
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| Synonyms: | CHEMBL300532 | [(6-Bromo-pyridin-3-ylamino)-phosphono-methyl]-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C6H9BrN2O6P2 |
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| Mol. Mass. | 346.997 |
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| SMILES | OP(O)(=O)C(Nc1ccc(Br)nc1)P(O)(O)=O |
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| Structure | 
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