| Reaction Details |
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 | Report a problem with these data |
| Target | Polyprenyl synthetase family protein |
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| Ligand | BDBM50138038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_69823 (CHEMBL679572) |
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| IC50 | >100000±n/a nM |
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| Citation |  Ghosh, S; Chan, JM; Lea, CR; Meints, GA; Lewis, JC; Tovian, ZS; Flessner, RM; Loftus, TC; Bruchhaus, I; Kendrick, H; Croft, SL; Kemp, RG; Kobayashi, S; Nozaki, T; Oldfield, E Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem47:175-87 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyprenyl synthetase family protein |
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| Name: | Polyprenyl synthetase family protein |
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| Synonyms: | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41078.35 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_330072 |
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| Residue: | 362 |
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| Sequence: | MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
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| BDBM50138038 |
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| n/a |
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| Name | BDBM50138038 |
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| Synonyms: | (4-butoxyphenyl)aminomethyelene-1,1-bisphosphonate | (4-butoxyphenylamino)methylenediphosphonic acid | CHEMBL434978 | [(4-Butoxy-phenylamino)-phosphono-methyl]-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C11H19NO7P2 |
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| Mol. Mass. | 339.2186 |
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| SMILES | CCCCOc1ccc(NC(P(O)(O)=O)P(O)(O)=O)cc1 |
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| Structure | 
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