| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyprenyl synthetase family protein |
|---|
| Ligand | BDBM50135833 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_69823 (CHEMBL679572) |
|---|
| IC50 | 360±n/a nM |
|---|
| Citation |  Ghosh, S; Chan, JM; Lea, CR; Meints, GA; Lewis, JC; Tovian, ZS; Flessner, RM; Loftus, TC; Bruchhaus, I; Kendrick, H; Croft, SL; Kemp, RG; Kobayashi, S; Nozaki, T; Oldfield, E Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem47:175-87 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyprenyl synthetase family protein |
|---|
| Name: | Polyprenyl synthetase family protein |
|---|
| Synonyms: | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41078.35 |
|---|
| Organism: | Plasmodium falciparum (isolate 3D7) |
|---|
| Description: | ChEMBL_330072 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
|
|
|
|---|
| BDBM50135833 |
|---|
| n/a |
|---|
| Name | BDBM50135833 |
|---|
| Synonyms: | (2-methylbutyl)aminomethylene-1,1-bisphosphonate | (2-methylbutylamino)methylenediphosphonic acid | (Bis-phosphono-methyl)-(2-methyl-butyl)-ammonium | CHEMBL56011 | [(2-Methyl-butylamino)-phosphono-methyl]-phosphonic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H17NO6P2 |
|---|
| Mol. Mass. | 261.1498 |
|---|
| SMILES | CCC(C)CN=C(P(O)(O)O)P(O)(O)=O |w:5.4| |
|---|
| Structure | 
|
|---|
Search and Browse
