| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilins-associated rhomboid-like protein, mitochondrial |
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| Ligand | BDBM50572958 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2118696 (CHEMBL4827762) |
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| IC50 | 8800±n/a nM |
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| Citation |  Parsons, WH; Rutland, NT; Crainic, JA; Cardozo, JM; Chow, AS; Andrews, CL; Sheehan, BK Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL. Bioorg Med Chem Lett49:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilins-associated rhomboid-like protein, mitochondrial |
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| Name: | Presenilins-associated rhomboid-like protein, mitochondrial |
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| Synonyms: | 3.4.21.105 | Mitochondrial intramembrane cleaving protease PARL | P-beta | PARL | PARL_HUMAN | PSARL | PSARL | Pbeta | Presenilins-associated rhomboid-like protein, mitochondrial |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42212.72 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_120480 |
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| Residue: | 379 |
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| Sequence: | MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV
EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ
YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF
CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL
GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF
LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL
VKIWHEIRTNGPKKGGGSK
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| BDBM50572958 |
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| n/a |
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| Name | BDBM50572958 |
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| Synonyms: | CHEMBL4856971 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10ClNO5S |
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| Mol. Mass. | 351.762 |
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| SMILES | Clc1ccccc1C(=O)OCN1C(=O)c2ccccc2S1(=O)=O |
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| Structure | 
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