Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50139008 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_147064 (CHEMBL754884) |
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Ki | 179±n/a nM |
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Citation | Tömböly, C; Kövér, KE; Péter, A; Tourwé, D; Biyashev, D; Benyhe, S; Borsodi, A; Al-Khrasani, M; Rónai, AZ; Tóth, G Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. J Med Chem47:735-43 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40465.04 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. |
Residue: | 372 |
Sequence: | MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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BDBM50139008 |
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n/a |
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Name | BDBM50139008 |
Synonyms: | (S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid [(1S,2S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-propyl]-amide | CHEMBL423466 |
Type | Small organic molecule |
Emp. Form. | C33H39N5O5 |
Mol. Mass. | 585.6933 |
SMILES | C[C@H]([C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)c1ccccc1 |
Structure |
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