Ki Summary

Reaction Details

Report a problem with these data

Target

Kappa-type opioid receptor

Ligand

BDBM50139016

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_145838 (CHEMBL755496)

990±n/a nM

Citation

Tömböly, C; Kövér, KE; Péter, A; Tourwé, D; Biyashev, D; Benyhe, S; Borsodi, A; Al-Khrasani, M; Rónai, AZ; Tóth, G Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. J Med Chem47:735-43 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Kappa-type opioid receptor

Name:

Kappa-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

42692.90

Organism:

Rattus norvegicus (rat)

Description:

P34975

Residue:

380

Sequence:

MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV

BDBM50139016

n/a

Name

BDBM50139016

Synonyms:

(R)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-1-oxo-propyl]-pyrrolidine-2-carboxylic acid [1-((S)-(S)-1-(S)-carbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-propyl]-amide | (S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid [(1R,2S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-propyl]-amide | CHEMBL355367

Type

Small organic molecule

Emp. Form.

C33H39N5O5

Mol. Mass.

585.6933

SMILES

C[C@H]([C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)c1ccccc1

Structure