| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50141017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53473 (CHEMBL665598) |
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| IC50 | 1900±n/a nM |
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| Citation |  Rosowsky, A; Forsch, RA; Sibley, CH; Inderlied, CB; Queener, SF New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. J Med Chem47:1475-86 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50141017 |
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| n/a |
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| Name | BDBM50141017 |
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| Synonyms: | 2-[3-(2,4-Diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenylethynyl]-benzoic acid | CHEMBL34378 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4O3 |
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| Mol. Mass. | 374.3926 |
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| SMILES | COc1ccc(cc1Cc1cnc(N)nc1N)C#Cc1ccccc1C(O)=O |
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| Structure | 
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