Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM50141016 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_53473 (CHEMBL665598) |
---|
IC50 | 710±n/a nM |
---|
Citation | Rosowsky, A; Forsch, RA; Sibley, CH; Inderlied, CB; Queener, SF New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. J Med Chem47:1475-86 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
BDBM50141016 |
---|
n/a |
---|
Name | BDBM50141016 |
Synonyms: | 2-{3-[3-(2,4-Diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenyl]-propoxy}-benzoic acid | CHEMBL289908 |
Type | Small organic molecule |
Emp. Form. | C22H24N4O4 |
Mol. Mass. | 408.4504 |
SMILES | COc1ccc(CCCOc2ccccc2C(O)=O)cc1Cc1cnc(N)nc1N |
Structure |
|