| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1A |
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| Ligand | BDBM463444 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2125495 (CHEMBL4834840) |
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| EC50 | 0.035000±n/a nM |
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| Citation |  Ferreira, MA; Azevedo, H; Mascarello, A; Segretti, ND; Russo, E; Russo, V; Guimarães, CRW Discovery of J Med Chem64:1904-1929 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1A |
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| Name: | Melatonin receptor type 1A |
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| Synonyms: | MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A |
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| Type: | Enzyme |
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| Mol. Mass.: | 39392.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48039 |
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| Residue: | 350 |
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| Sequence: | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
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| BDBM463444 |
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| n/a |
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| Name | BDBM463444 |
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| Synonyms: | US10781182, Compound IA2-121 | US11091445, Compound code IA2-121 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18ClN3O3 |
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| Mol. Mass. | 311.764 |
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| SMILES | CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O |
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| Structure | 
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