| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin K-dependent protein C |
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| Ligand | BDBM50142152 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_27850 |
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| IC50 | >11000±n/a nM |
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| Citation |  Zhang, P; Bao, L; Zuckett, JF; Jia, ZJ; Woolfrey, J; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity. Bioorg Med Chem Lett14:989-93 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin K-dependent protein C |
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| Name: | Vitamin K-dependent protein C |
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| Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 52067.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 461 |
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| Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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| BDBM50142152 |
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| n/a |
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| Name | BDBM50142152 |
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| Synonyms: | 5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-piperidin-1-ylmethyl-benzoylamino)-benzamide | CHEMBL368614 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24Cl2N4O2 |
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| Mol. Mass. | 483.39 |
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| SMILES | Clc1ccc(NC(=O)c2cc(Cl)ccc2NC(=O)c2ccc(CN3CCCCC3)cc2)nc1 |
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| Structure | 
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