| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1A |
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| Ligand | BDBM103443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2125824 (CHEMBL4835169) |
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| EC50 | 0.015000±n/a nM |
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| Citation |  Hoashi, Y; Takai, T; Kosugi, Y; Nakashima, M; Nakayama, M; Hirai, K; Uchikawa, O; Koike, T Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist. J Med Chem64:3059-3074 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1A |
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| Name: | Melatonin receptor type 1A |
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| Synonyms: | MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A |
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| Type: | Enzyme |
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| Mol. Mass.: | 39392.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48039 |
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| Residue: | 350 |
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| Sequence: | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
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| BDBM103443 |
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| n/a |
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| Name | BDBM103443 |
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| Synonyms: | US8552037, 90 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18N2O2 |
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| Mol. Mass. | 258.3156 |
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| SMILES | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c12 |r| |
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| Structure | 
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