| Reaction Details |
|---|
 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Ligand | BDBM194644 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2125910 (CHEMBL4835255) |
|---|
| IC50 | 2.0±n/a nM |
|---|
| Citation |  Brebion, F; Gosmini, R; Deprez, P; Varin, M; Peixoto, C; Alvey, L; Jary, H; Bienvenu, N; Triballeau, N; Blanque, R; Cottereaux, C; Christophe, T; Vandervoort, N; Mollat, P; Touitou, R; Leonard, P; De Ceuninck, F; Botez, I; Monjardet, A; van der Aar, E; Amantini, D Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis. J Med Chem64:2937-2952 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 101769.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNA0 |
|---|
| Residue: | 930 |
|---|
| Sequence: | MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
|
|
|
|---|
| BDBM194644 |
|---|
| n/a |
|---|
| Name | BDBM194644 |
|---|
| Synonyms: | US9206139, 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22F3N3O3 |
|---|
| Mol. Mass. | 409.4022 |
|---|
| SMILES | FC(F)(F)c1ccc(C[C@@H](C2CC2)C(=O)NC[C@]2(NC(=O)NC2=O)C2CC2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
