| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 6 |
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| Ligand | BDBM50576849 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2127959 (CHEMBL4837388) |
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| IC50 | >50000±n/a nM |
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| Citation |  Kumar, S; Jaipuri, FA; Waldo, JP; Potturi, H; Marcinowicz, A; Adams, J; Van Allen, C; Zhuang, H; Vahanian, N; Link, C; Brincks, EL; Mautino, MR Discovery of indoximod prodrugs and characterization of clinical candidate NLG802. Eur J Med Chem198:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 6 |
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| Name: | Solute carrier family 22 member 6 |
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| Synonyms: | OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | S22A6_HUMAN | SLC22A6 | hOAT1 | hPAHT | hROAT1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61831.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487359 |
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| Residue: | 563 |
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| Sequence: | MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
RQQQEHQKYMVPLQASAQEKNGL
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| BDBM50576849 |
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| n/a |
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| Name | BDBM50576849 |
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| Synonyms: | CHEMBL4876008 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H30ClN3O3 |
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| Mol. Mass. | 395.924 |
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| SMILES | Cl.CCOC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CC(C)C |r| |
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| Structure | 
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