| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase 1, cytoplasmic |
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| Ligand | BDBM50576851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2128404 (CHEMBL4837833) |
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| IC50 | 13±n/a nM |
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| Citation |  Ayoup, MS; Abu-Serie, MM; Abdel-Hamid, H; Teleb, M Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy. Eur J Med Chem220:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin reductase 1, cytoplasmic |
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| Name: | Thioredoxin reductase 1, cytoplasmic |
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| Synonyms: | GRIM-12 | GRIM12 | Gene associated with retinoid-IFN-induced mortality 12 protein | KDRF | KM-102-derived reductase-like factor | TR | TRXR1_HUMAN | TXNRD1 | Thioredoxin reductase 1 | Thioredoxin reductase 1 (TrxR) | Thioredoxin reductase TR1 |
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| Type: | Protein |
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| Mol. Mass.: | 70761.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16881 |
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| Residue: | 648 |
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| Sequence: | MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCG
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| BDBM50576851 |
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| n/a |
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| Name | BDBM50576851 |
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| Synonyms: | CHEMBL1876217 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10N2O2 |
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| Mol. Mass. | 238.2414 |
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| SMILES | Oc1ccccc1-c1nc(no1)-c1ccccc1 |
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| Structure | 
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