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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | NADPH oxidase 4 | ||
| Ligand | BDBM2579 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2128408 (CHEMBL4837837) | ||
| IC50 | 71±n/a nM | ||
| Citation |  Ayoup, MS; Abu-Serie, MM; Abdel-Hamid, H; Teleb, M Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy. Eur J Med Chem220:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| NADPH oxidase 4 | |||
| Name: | NADPH oxidase 4 | ||
| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 66954.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_792879 | ||
| Residue: | 578 | ||
| Sequence: |
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| BDBM2579 | |||
| n/a | |||
| Name | BDBM2579 | ||
| Synonyms: | (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one | CHEMBL388978 | Staurosporin, 4 | Staurosporine | Staurosporine, 8 | US20240002365, Compound staurosporine | US9206188, Staurosporine | US9226923, Staurosporine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H26N4O3 | ||
| Mol. Mass. | 466.531 | ||
| SMILES | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| | ||
| Structure | 
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