| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50143770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_214322 (CHEMBL818350) |
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| EC50 | 0.18±n/a nM |
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| Citation |  Tocchini-Valentini, G; Rochel, N; Wurtz, JM; Moras, D Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modificatio J Med Chem47:1956-61 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 48288.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11473 |
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| Residue: | 427 |
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| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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| BDBM50143770 |
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| n/a |
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| Name | BDBM50143770 |
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| Synonyms: | (1R,3S)-5-[2-[(3aS,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-3a,7a-dimethyl-octahydro-inden-(4Z)-ylidene]-eth-(E)-ylidene]-4-methylene-cyclohexane-1,3-diol | CHEMBL299680 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H46O3 |
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| Mol. Mass. | 430.663 |
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| SMILES | C[C@H](CCCC(C)(C)O)C1CC[C@@]2(C)\C(CCC[C@]12C)=C/C=C1\C[C@@H](O)C[C@H](O)C1=C |
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| Structure | 
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