| Reaction Details |
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 | Report a problem with these data |
| Target | Envelope phospholipase F13 |
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| Ligand | BDBM50577045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2128845 (CHEMBL4838274) |
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| IC50 | 270±n/a nM |
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| Citation |  Shiryaev, VA; Skomorohov, MY; Leonova, MV; Bormotov, NI; Serova, OA; Shishkina, LN; Agafonov, AP; Maksyutov, RA; Klimochkin, YN Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity. Eur J Med Chem221:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Envelope phospholipase F13 |
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| Name: | Envelope phospholipase F13 |
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| Synonyms: | 3.1.1.- | 37 kDa protein | Envelope phospholipase F13 | OPG057 | PG057_VACCW | Palmitoylated EV membrane protein | p37K |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41798.24 |
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| Organism: | Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR)) |
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| Description: | ChEMBL_118391 |
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| Residue: | 372 |
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| Sequence: | MWPFASVPAGAKCRLVETLPENMDFRSDHLTTFECFNEIITLAKKYIYIASFCCNPLSTT
RGALIFDKLKEASEKGIKIIVLLDERGKRNLGELQSHCPDINFITVNIDKKNNVGLLLGC
FWVSDDERCYVGNASFTGGSIHTIKTLGVYSDYPPLATDLRRRFDTFKAFNSAKNSWLNL
CSAACCLPVSTAYHIKNPIGGVFFTDSPEHLLGYSRDLDTDVVIDKLKSAKTSIDIEHLA
IVPTTRVDGNSYYWPDIYNSIIEAAINRGVKIRLLVGNWDKNDVYSMATARSLDALCVQN
DLSVKVFTIQNNTKLLIVDDEYVHITSANFDGTHYQNHGFVSFNSIDKQLVSEAKKIFER
DWVSSHSKSLKI
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| BDBM50577045 |
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| n/a |
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| Name | BDBM50577045 |
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| Synonyms: | CHEMBL4871145 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22F3NO |
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| Mol. Mass. | 337.3793 |
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| SMILES | FC(F)(F)c1ccc(cc1)C(=O)NCC12CC3CC(CC(C3)C1)C2 |TLB:13:14:17:21.20.19,THB:15:16:19:23.14.22,15:14:17.16.21:19,22:14:17:21.20.19,22:20:17:23.15.14| |
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| Structure | 
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