Reaction Details | |||
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Target | Mitogen-activated protein kinase kinase kinase kinase 4 | ||
Ligand | BDBM50469353 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2129296 (CHEMBL4838725) | ||
IC50 | 2.7±n/a nM | ||
Citation | Zheng, H; Zhao, J; Li, B; Zhang, W; Stashko, MA; Minson, KA; Huey, MG; Zhou, Y; Earp, HS; Kireev, D; Graham, DK; DeRyckere, D; Frye, SV; Wang, X UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem220:0 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase kinase kinase kinase 4 | |||
Name: | Mitogen-activated protein kinase kinase kinase kinase 4 | ||
Synonyms: | HGK | HPK/GCK-like kinase HGK | KIAA0687 | M4K4_HUMAN | MAP4K4 | MAP4K4 (HGK) | MAPK/ERK kinase kinase kinase 4 | MEK kinase kinase 4 | MEKKK 4 | Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) | NIK | Nck-interacting kinase | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 142114.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O95819 | ||
Residue: | 1239 | ||
Sequence: |
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BDBM50469353 | |||
n/a | |||
Name | BDBM50469353 | ||
Synonyms: | CHEMBL4283353 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H44N6O | ||
Mol. Mass. | 504.71 | ||
SMILES | CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1 |r,wU:13.12,wD:16.16,3.3,(17.07,-10.92,;18.4,-10.15,;19.74,-10.92,;21.07,-10.15,;21.07,-8.61,;22.4,-10.92,;23.74,-10.15,;23.74,-8.61,;25.07,-7.84,;26.4,-8.6,;27.88,-8.12,;28.79,-9.38,;27.88,-10.63,;28.63,-11.97,;30.16,-12,;30.91,-13.35,;30.11,-14.67,;30.85,-16.02,;28.57,-14.64,;27.83,-13.29,;26.4,-10.15,;25.07,-10.92,;28.59,-6.76,;30.13,-6.7,;30.84,-5.34,;30.02,-4.03,;30.73,-2.67,;32.27,-2.6,;33,-3.97,;34.51,-4.24,;35.67,-3.22,;35.61,-1.69,;36.96,-.95,;34.36,-.79,;32.87,-1.2,;28.47,-4.1,;27.77,-5.47,)| | ||
Structure |