| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-10 |
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| Ligand | BDBM50577131 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2129504 (CHEMBL4838933) |
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| IC50 | >10000±n/a nM |
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| Citation |  Li, X; Hong, D; Zhang, M; Xu, L; Zhou, Y; Li, J; Liu, T Development of peptide epoxyketones as selective immunoproteasome inhibitors. Eur J Med Chem221:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-10 |
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| Name: | Proteasome subunit beta type-10 |
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| Synonyms: | LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28940.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 273 |
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| Sequence: | MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
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| BDBM50577131 |
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| n/a |
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| Name | BDBM50577131 |
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| Synonyms: | CHEMBL4855915 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H42N4O7 |
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| Mol. Mass. | 594.6985 |
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| SMILES | COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r| |
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| Structure | 
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