| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 4 |
|---|
| Ligand | BDBM50577689 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2130725 (CHEMBL4840154) |
|---|
| IC50 | 83±n/a nM |
|---|
| Citation |  Kwong, AJ; Pham, TND; Oelschlager, HE; Munshi, HG; Scheidt, KA Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma. ACS Med Chem Lett12:1559-1567 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 4 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 4 |
|---|
| Synonyms: | JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44294.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1460558 |
|---|
| Residue: | 399 |
|---|
| Sequence: | MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
|
|
|
|---|
| BDBM50577689 |
|---|
| n/a |
|---|
| Name | BDBM50577689 |
|---|
| Synonyms: | CHEMBL4866649 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H15FN4O3S |
|---|
| Mol. Mass. | 410.422 |
|---|
| SMILES | NC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
