| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 7 |
|---|
| Ligand | BDBM50577688 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2130726 (CHEMBL4840155) |
|---|
| IC50 | 1300±n/a nM |
|---|
| Citation |  Kwong, AJ; Pham, TND; Oelschlager, HE; Munshi, HG; Scheidt, KA Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma. ACS Med Chem Lett12:1559-1567 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 7 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 7 |
|---|
| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47502.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14733 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
|
|
|
|---|
| BDBM50577688 |
|---|
| n/a |
|---|
| Name | BDBM50577688 |
|---|
| Synonyms: | CHEMBL4875545 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H16FN3O3S |
|---|
| Mol. Mass. | 409.433 |
|---|
| SMILES | CC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
