| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine proteinase falcipain 2a |
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| Ligand | BDBM50578406 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2132868 (CHEMBL4842478) |
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| Ki | 3320±n/a nM |
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| Citation |  Aratikatla, EK; Kalamuddin, M; Rana, KC; Datta, G; Asad, M; Sundararaman, S; Malhotra, P; Mohmmed, A; Bhattacharya, AK Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials. Eur J Med Chem220:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine proteinase falcipain 2a |
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| Name: | Cysteine proteinase falcipain 2a |
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| Synonyms: | Cysteine protease falcipain-2 |
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| Type: | Protein |
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| Mol. Mass.: | 55996.21 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q9NBD4 |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISHQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFILFYFTPNFR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM50578406 |
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| n/a |
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| Name | BDBM50578406 |
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| Synonyms: | CHEMBL4869807 |
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| Type | Small organic molecule |
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| Emp. Form. | C45H64N3O12P |
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| Mol. Mass. | 869.9763 |
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| SMILES | [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@H](OC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NC(\C=C\P(=O)(OCC)OCC)c1ccccc1)[C@@H]2C)O4 |r| |
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| Structure | 
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