| Reaction Details |
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 | Report a problem with these data |
| Target | Wee1-like protein kinase |
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| Ligand | BDBM50579220 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2134694 (CHEMBL4844304) |
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| IC50 | 3.7±n/a nM |
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| Citation |  Huang, PQ; Boren, BC; Hegde, SG; Liu, H; Unni, AK; Abraham, S; Hopkins, CD; Paliwal, S; Samatar, AA; Li, J; Bunker, KD Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer. J Med Chem64:13004-13024 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Wee1-like protein kinase |
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| Name: | Wee1-like protein kinase |
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| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71599.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1445054 |
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| Residue: | 646 |
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| Sequence: | MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
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| BDBM50579220 |
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| n/a |
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| Name | BDBM50579220 |
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| Synonyms: | CHEMBL4868683 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36N8O2 |
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| Mol. Mass. | 540.6592 |
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| SMILES | CC[C@@]1(O)CCCc2ccc(nc12)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12 |r| |
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| Structure | 
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