Reaction Details | |||
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Target | Disintegrin and metalloproteinase domain-containing protein 17 | ||
Ligand | BDBM50146476 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_212749 | ||
IC50 | 2±n/a nM | ||
Citation | Kamei, N; Tanaka, T; Kawai, K; Miyawaki, K; Okuyama, A; Murakami, Y; Arakawa, Y; Haino, M; Harada, T; Shimano, M Reverse hydroxamate-based selective TACE inhibitors. Bioorg Med Chem Lett14:2897-900 (2004) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Disintegrin and metalloproteinase domain-containing protein 17 | |||
Name: | Disintegrin and metalloproteinase domain-containing protein 17 | ||
Synonyms: | ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE) | ||
Type: | Enzyme | ||
Mol. Mass.: | 93007.89 | ||
Organism: | Homo sapiens (Human) | ||
Description: | |||
Residue: | 824 | ||
Sequence: |
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BDBM50146476 | |||
n/a | |||
Name | BDBM50146476 | ||
Synonyms: | CHEMBL99995 | N-Hydroxy-N-{1-(4-hydroxyimino-cyclohexylidenemethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide | ||
Type | Small organic molecule | ||
Emp. Form. | C27H29N3O6S | ||
Mol. Mass. | 523.601 | ||
SMILES | Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(C=C2CCC(CC2)N=O)N(O)C=O)c2ccccc2n1 |(15.21,-2.83,;13.88,-2.06,;13.87,-.52,;12.54,.23,;12.53,1.77,;13.84,2.56,;15.19,1.79,;15.19,.26,;16.53,-.5,;17.86,.27,;17.85,1.82,;16.5,2.58,;19.19,-.49,;18.44,-1.83,;19.96,.86,;20.52,-1.26,;21.87,-.52,;21.87,1,;23.18,1.81,;24.55,1.09,;25.86,1.91,;25.81,3.45,;24.44,4.17,;23.13,3.35,;27.11,4.26,;28.47,3.54,;23.19,-1.34,;24.55,-.59,;23.15,-2.87,;24.45,-3.69,;11.21,-.54,;9.87,.23,;8.55,-.54,;8.54,-2.08,;9.88,-2.85,;11.21,-2.08,;12.54,-2.85,)| | ||
Structure |