Reaction Details |
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Target | 72 kDa type IV collagenase |
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Ligand | BDBM50146471 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_104554 |
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IC50 | 7000±n/a nM |
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Citation | Kamei, N; Tanaka, T; Kawai, K; Miyawaki, K; Okuyama, A; Murakami, Y; Arakawa, Y; Haino, M; Harada, T; Shimano, M Reverse hydroxamate-based selective TACE inhibitors. Bioorg Med Chem Lett14:2897-900 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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72 kDa type IV collagenase |
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Name: | 72 kDa type IV collagenase |
Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
Type: | Enzyme |
Mol. Mass.: | 73870.36 |
Organism: | Homo sapiens (Human) |
Description: | P08253 |
Residue: | 660 |
Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
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BDBM50146471 |
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n/a |
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Name | BDBM50146471 |
Synonyms: | CHEMBL431226 | N-{1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-N-hydroxy-formamide |
Type | Small organic molecule |
Emp. Form. | C28H32N2O7S |
Mol. Mass. | 540.628 |
SMILES | Cc1cc(COc2ccc(cc2)S(=O)(=O)CC(C2CCC3(CC2)OCCO3)N(O)C=O)c2ccccc2n1 |
Structure |
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