| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4E |
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| Ligand | BDBM50579405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2135250 (CHEMBL4844860) |
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| IC50 | 5000±n/a nM |
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| Citation |  Carter, DM; Specker, E; Ma?ecki, PH; Przygodda, J; Dudaniec, K; Weiss, MS; Heinemann, U; Nazaré, M; Gohlke, U Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J Med Chem64:14266-14282 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4E |
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| Name: | Lysine-specific demethylase 4E |
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| Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56815.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2RXH2 |
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| Residue: | 506 |
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| Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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| BDBM50579405 |
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| n/a |
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| Name | BDBM50579405 |
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| Synonyms: | CHEMBL4874810 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N4O |
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| Mol. Mass. | 304.3458 |
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| SMILES | CCc1nn(c(O)c1-c1ccccc1)-c1nc2ccccc2[nH]1 |
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| Structure | 
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