| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50146606 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_63215 |
|---|
| IC50 | 0.120000±n/a nM |
|---|
| Citation |  Funk, OF; Kettmann, V; Drimal, J; Langer, T Chemical function based pharmacophore generation of endothelin-A selective receptor antagonists. J Med Chem47:2750-60 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48256.91 |
|---|
| Organism: | RAT |
|---|
| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
|
|
|
|---|
| BDBM50146606 |
|---|
| n/a |
|---|
| Name | BDBM50146606 |
|---|
| Synonyms: | (Z)-2-Benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(3,4,5-triethoxy-benzyl)-but-2-enoic acid | CHEMBL177378 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H32O9 |
|---|
| Mol. Mass. | 548.5804 |
|---|
| SMILES | CCOc1cc(C\C(C(=O)c2ccc(OC)cc2)=C(\C(O)=O)c2ccc3OCOc3c2)cc(OCC)c1OCC |
|---|
| Structure | 
|
|---|
Search and Browse
