| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50112701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63215 |
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| IC50 | 110±n/a nM |
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| Citation |  Funk, OF; Kettmann, V; Drimal, J; Langer, T Chemical function based pharmacophore generation of endothelin-A selective receptor antagonists. J Med Chem47:2750-60 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50112701 |
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| n/a |
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| Name | BDBM50112701 |
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| Synonyms: | 2-Benzo[1,3]dioxol-5-yl-6-isopropyl-4-(4-methoxy-phenyl)-2H-chromene-3-carboxylic acid | CHEMBL64244 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24O6 |
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| Mol. Mass. | 444.4759 |
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| SMILES | COc1ccc(cc1)C1=C(C(Oc2ccc(cc12)C(C)C)c1ccc2OCOc2c1)C(O)=O |t:9| |
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| Structure | 
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