Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Poly [ADP-ribose] polymerase tankyrase-2 | ||
| Ligand | BDBM50579981 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2146090 (CHEMBL5030370) | ||
| IC50 | 1.6±n/a nM | ||
| Citation |  Leenders, RGG; Brinch, SA; Sowa, ST; Amundsen-Isaksen, E; Galera-Prat, A; Murthy, S; Aertssen, S; Smits, JN; Nieczypor, P; Damen, E; Wegert, A; Nazaré, M; Lehtiö, L; Waaler, J; Krauss, S Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem64:17936-17949 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Poly [ADP-ribose] polymerase tankyrase-2 | |||
| Name: | Poly [ADP-ribose] polymerase tankyrase-2 | ||
| Synonyms: | (ARTD6 or PARP5b) | PARP5B | Poly [ADP-ribose] polymerase tankyrase-2 | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | TPoly [ADP-ribose] polymerase tankyrase-2 | Tankyrase 2 | Tankyrase II | Tankyrase-2 | Tankyrase-2 (TNKS-2) | Tankyrase-2 (TNKS2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 126937.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9H2K2 | ||
| Residue: | 1166 | ||
| Sequence: |
| ||
| BDBM50579981 | |||
| n/a | |||
| Name | BDBM50579981 | ||
| Synonyms: | CHEMBL5071436 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H20FN7O | ||
| Mol. Mass. | 465.4817 | ||
| SMILES | Fc1ccccc1-n1c(nnc1-c1ccccn1)[C@H]1C[C@@H](C1)NC(=O)c1cccc2nccnc12 |r,wU:20.25,wD:18.20,(66.64,-7.99,;66.03,-9.38,;66.93,-10.61,;66.31,-12.01,;64.8,-12.17,;63.9,-10.94,;64.53,-9.55,;63.63,-8.31,;64.11,-6.84,;62.86,-5.93,;61.61,-6.84,;62.09,-8.31,;61.19,-9.54,;61.81,-10.93,;60.92,-12.16,;59.4,-12,;58.78,-10.61,;59.67,-9.38,;65.58,-6.36,;66.95,-7.07,;67.66,-5.69,;66.28,-4.99,;69.13,-5.22,;69.46,-3.71,;68.3,-2.67,;70.93,-3.22,;71.24,-1.71,;72.7,-1.23,;73.86,-2.26,;73.54,-3.78,;74.68,-4.8,;74.37,-6.31,;72.89,-6.79,;71.75,-5.76,;72.07,-4.25,)| | ||
| Structure | 
| ||