Reaction Details |
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Target | Beta-secretase 2 |
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Ligand | BDBM50580217 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2147525 (CHEMBL5031871) |
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Ki | 0.290000±n/a nM |
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Citation | Ueno, T; Matsuoka, E; Asada, N; Yamamoto, S; Kanegawa, N; Ito, M; Ito, H; Moechars, D; Rombouts, FJR; Gijsen, HJM; Kusakabe, KI Discovery of Extremely Selective Fused Pyridine-Derived ?-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. J Med Chem64:14165-14174 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 2 |
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Name: | Beta-secretase 2 |
Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) |
Type: | Protein |
Mol. Mass.: | 56171.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Z0 |
Residue: | 518 |
Sequence: | MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
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BDBM50580217 |
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n/a |
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Name | BDBM50580217 |
Synonyms: | CHEMBL5093195 |
Type | Small organic molecule |
Emp. Form. | C19H16FN7O2 |
Mol. Mass. | 393.3744 |
SMILES | Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)Cn2nc(cc2C(N)=N1)C#N |r,c:28| |
Structure |
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