| Reaction Details |
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 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
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| Ligand | BDBM50085960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208056 |
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| IC50 | 9400±n/a nM |
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| Citation |  Gopalsamy, A; Kincaid, SL; Ellingboe, JW; Groeling, TM; Antrilli, TM; Krishnamurthy, G; Aulabaugh, A; Friedrichs, GS; Crandall, DL Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett14:3477-80 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tissue-type plasminogen activator |
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| Name: | Tissue-type plasminogen activator |
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| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
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| Type: | Enzyme |
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| Mol. Mass.: | 62931.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 562 |
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| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
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| BDBM50085960 |
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| n/a |
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| Name | BDBM50085960 |
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| Synonyms: | 2-{(E)-3-[3-(3,5-Bis-trifluoromethyl-benzyloxy)-phenyl]-but-2-enyl}-[1,2,4]oxadiazolidine-3,5-dione | 2-{3-[3-(3,5-Bis-trifluoromethyl-benzyloxy)-phenyl]-but-2-enyl}-[1,2,4]oxadiazolidine-3,5-dione | CHEMBL7251 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16F6N2O4 |
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| Mol. Mass. | 474.3532 |
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| SMILES | C\C(=C/Cn1oc(=O)[nH]c1=O)c1cccc(OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 |
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| Structure | 
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