Reaction Details |
| Report a problem with these data |
Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
---|
Ligand | BDBM50092485 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_205065 (CHEMBL810259) |
---|
IC50 | 5.8±n/a nM |
---|
Citation | Occhiato, EG; Ferrali, A; Menchi, G; Guarna, A; Danza, G; Comerci, A; Mancina, R; Serio, M; Garotta, G; Cavalli, A; De Vivo, M; Recanatini, M Synthesis, biological activity, and three-dimensional quantitative structure-activity relationship model for a series of benzo[c]quinolizin-3-ones, nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem47:3546-60 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
---|
Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
Type: | Enzyme |
Mol. Mass.: | 29472.80 |
Organism: | Homo sapiens (Human) |
Description: | P18405 |
Residue: | 259 |
Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
|
|
|
BDBM50092485 |
---|
n/a |
---|
Name | BDBM50092485 |
Synonyms: | 4-methyl-8-chloro-1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-one | 8-Chloro-4-methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-3-one | CHEMBL118446 |
Type | Small organic molecule |
Emp. Form. | C14H14ClNO |
Mol. Mass. | 247.72 |
SMILES | CC1=C2CCc3cc(Cl)ccc3N2CCC1=O |c:1| |
Structure |
|