Reaction Details |
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Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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Ligand | BDBM50149337 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_205065 (CHEMBL810259) |
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IC50 | 560±n/a nM |
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Citation | Occhiato, EG; Ferrali, A; Menchi, G; Guarna, A; Danza, G; Comerci, A; Mancina, R; Serio, M; Garotta, G; Cavalli, A; De Vivo, M; Recanatini, M Synthesis, biological activity, and three-dimensional quantitative structure-activity relationship model for a series of benzo[c]quinolizin-3-ones, nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem47:3546-60 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
Type: | Enzyme |
Mol. Mass.: | 29472.80 |
Organism: | Homo sapiens (Human) |
Description: | P18405 |
Residue: | 259 |
Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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BDBM50149337 |
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n/a |
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Name | BDBM50149337 |
Synonyms: | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-tert-butyl-phenyl ester | CHEMBL118824 |
Type | Small organic molecule |
Emp. Form. | C25H27NO3 |
Mol. Mass. | 389.4868 |
SMILES | CC1=C2CCc3cc(ccc3N2CCC1=O)C(=O)Oc1ccc(cc1)C(C)(C)C |c:1| |
Structure |
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