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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50149657 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_302831 (CHEMBL838621) | ||
| Ki | 1.7±n/a nM | ||
| Citation |  Huang, CQ; Wilcoxen, KM; Grigoriadis, DE; McCarthy, JR; Chen, C Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists. Bioorg Med Chem Lett14:3943-7 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50149657 | |||
| n/a | |||
| Name | BDBM50149657 | ||
| Synonyms: | Benzyl-[3-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amine | CHEMBL361314 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23ClF3N5 | ||
| Mol. Mass. | 473.921 | ||
| SMILES | CCCN(Cc1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1Cl)C(F)(F)F |(3.1,6.22,;3.69,4.78,;2.76,3.59,;3.34,2.16,;4.88,1.95,;5.46,.53,;4.51,-.68,;5.11,-2.12,;6.63,-2.32,;7.57,-1.08,;6.98,.34,;2.41,.93,;2.99,-.47,;2.05,-1.69,;2.64,-3.11,;.54,-1.5,;-.04,-.08,;-1.49,.44,;-1.46,1.98,;-2.66,2.91,;.03,2.4,;.89,1.12,;-2.89,-.26,;-2.89,-1.78,;-4.22,-2.55,;-5.55,-1.78,;-5.55,-.26,;-4.22,.53,;-4.22,2.05,;-6.88,-2.55,;-8.11,-3.25,;-8.4,-1.99,;-7.14,-4.14,)| | ||
| Structure | 
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