Reaction Details |
| Report a problem with these data |
Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Ligand | BDBM50581628 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2151789 (CHEMBL5036251) |
---|
IC50 | 0.179000±n/a nM |
---|
Citation | Sabnis, RW Biaryl Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML). ACS Med Chem Lett13:158-159 (2022) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
BDBM50581628 |
---|
n/a |
---|
Name | BDBM50581628 |
Synonyms: | CHEMBL5077700 |
Type | Small organic molecule |
Emp. Form. | C24H25F4N3O3 |
Mol. Mass. | 479.4672 |
SMILES | C[C@H](Oc1cc(-c2cn(C)c(n2)C(C)(C)O)c(F)cc1C(=O)Nc1ccccc1C)C(F)(F)F |r| |
Structure |
|