| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine synthase isoform type-2 |
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| Ligand | BDBM507762 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2152068 (CHEMBL5036615) |
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| IC50 | 22±n/a nM |
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| Citation |  De Fusco, C; Schimpl, M; Börjesson, U; Cheung, T; Collie, I; Evans, L; Narasimhan, P; Stubbs, C; Vazquez-Chantada, M; Wagner, DJ; Grondine, M; Sanders, MG; Tentarelli, S; Underwood, E; Argyrou, A; Smith, JM; Lynch, JT; Chiarparin, E; Robb, G; Bagal, SK; Scott, JS Fragment-Based Design of a Potent MAT2a Inhibitor and J Med Chem64:6814-6826 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine synthase isoform type-2 |
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| Name: | S-adenosylmethionine synthase isoform type-2 |
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| Synonyms: | AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II |
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| Type: | Protein |
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| Mol. Mass.: | 43659.65 |
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| Organism: | Human |
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| Description: | P31153 |
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| Residue: | 395 |
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| Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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| BDBM507762 |
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| n/a |
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| Name | BDBM507762 |
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| Synonyms: | 7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(1H)-one | US11046691, Compound 24 | US11084798, Cpd No 24 | US11130759, Cpd. No. 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClN3O |
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| Mol. Mass. | 299.755 |
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| SMILES | CN(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 |
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| Structure | 
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