Reaction Details |
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Target | S-adenosylmethionine synthase isoform type-2 |
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Ligand | BDBM50581709 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2152068 (CHEMBL5036615) |
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IC50 | 16±n/a nM |
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Citation | De Fusco, C; Schimpl, M; Börjesson, U; Cheung, T; Collie, I; Evans, L; Narasimhan, P; Stubbs, C; Vazquez-Chantada, M; Wagner, DJ; Grondine, M; Sanders, MG; Tentarelli, S; Underwood, E; Argyrou, A; Smith, JM; Lynch, JT; Chiarparin, E; Robb, G; Bagal, SK; Scott, JS Fragment-Based Design of a Potent MAT2a Inhibitor and J Med Chem64:6814-6826 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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S-adenosylmethionine synthase isoform type-2 |
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Name: | S-adenosylmethionine synthase isoform type-2 |
Synonyms: | AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II |
Type: | Protein |
Mol. Mass.: | 43659.65 |
Organism: | Human |
Description: | P31153 |
Residue: | 395 |
Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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BDBM50581709 |
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n/a |
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Name | BDBM50581709 |
Synonyms: | CHEMBL5075691 |
Type | Small organic molecule |
Emp. Form. | C17H16ClN3O |
Mol. Mass. | 313.781 |
SMILES | CN(C)c1nc(=O)n(-c2cccc(C)c2)c2cc(Cl)ccc12 |
Structure |
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